Work (art, fic, whatever) focused on straight pairings. Josh and Mindy? Totally fine. Drake and his flavor of the week? Sure thing, and that means OCs are cool too. Heck, Drake and Mindy, if you like love/hate! Or even Megan with a boyfriend, or Walter and Audrey, without who we wouldn't have the awesome blended family we know and love... or whatever else comes to mind!